Pharmaceutical Temperature Control Unit

Pharmaceutical reactor temperature control TCU temperature control system, referred to as TCU system, is an advanced temperature control equipment. It uses advanced sensors and control systems to monitor the temperature in the reactor in real time, and adjusts it according to the preset temperature curve to ensure the constant and accurate temperature during the pharmaceutical reaction.

In the pharmaceutical reaction process, temperature is one of the key factors affecting product quality and efficiency. Too high or too low temperature may cause the chemical reaction to get out of control and even produce harmful substances. The TCU system was born to solve this problem. It can automatically adjust the heating or cooling speed according to the characteristics of the pharmaceutical reaction to keep the temperature in the reactor at the best state.

Not only that, the TCU system is also highly intelligent and automated. It can realize remote monitoring and control through linkage with the reactor, greatly improving production efficiency and safety. At the same time, the TCU system also has a fault self-diagnosis function. Once a fault occurs, it can quickly locate and issue an alarm to escort the production of pharmaceutical companies.

Introduction of pharmaceutical temperature control unit

Single fluid control: It can provide closed, repeatable temperature control, avoiding the need for traditional equipment and facility replacement and jacket maintenance, and non-contact control only in the jacket of the reaction vessel.

Temperature control: You can choose to control the reaction process temperature and the single fluid temperature, and the temperature difference between the reactor process temperature and the heat transfer single fluid temperature can be set and controlled.

Optional functions: RS-485 communication interface realizes remote control, heating power switching or automatic adjustment, instant cooling shutdown function, control temperature range: -120 ～ +350℃.

Temperature control accuracy: ±0.01℃, ±0.03℃, ±0.5℃, ±1℃, circulating medium: circulating water or heat transfer oil can be selected, cooling method: indirect cooling or direct cooling, control method: PID circuit board or PLC control system.

Pharmaceutical Temperature Control Unit

Factors to consider when selecting a pharmaceutical temperature control unit

1. Temperature range and accuracy

Temperature range: In the pharmaceutical process, the processes involved usually need to be carried out in a relatively wide temperature range. For example, the reaction process may need to be heated to a high temperature (such as above 250°C), while the cooling process needs to be cooled to a lower temperature (such as -120°C). Therefore, the selected TCU needs to have sufficient temperature control range and adjustability.

Temperature control accuracy: In the pharmaceutical industry, high temperature control accuracy is required, especially in sensitive chemical reactions, drug synthesis, crystallization and other processes. TCU needs to provide a high-precision temperature control system, usually requiring a temperature control accuracy of ±0.1°C or even higher.

2. Heat source type

Water or oil heating:

Water-heated TCU: Suitable for lower temperature requirements, usually controlled at around 100°C. The water heating system provides good thermal conductivity and is suitable for occasions requiring medium and low temperature control. Water-heated TCUs are usually more efficient, but their use in high temperature environments may be subject to certain restrictions.

Oil-heated TCU: Used for applications requiring higher temperatures, oil heating systems have higher temperature stability than water heating systems and are suitable for high temperature or high pressure environments. Oil heating equipment is often used in more complex pharmaceutical processes, especially during high-temperature curing or heating.

3. Heat exchange efficiency

The heat exchange efficiency of TCU is one of its core indicators, which is directly related to the heat exchange speed of the system and the temperature control response speed. In the pharmaceutical industry, since some processes (such as dissolution, evaporation, reaction, etc.) require fast and uniform heating or cooling, good heat exchange effect is essential to improve production efficiency.

Plate heat exchangers and shell and tube heat exchangers are common heat exchange technologies. When choosing, factors such as the fluid flow rate, pressure loss, and space limitations required by the system should be considered.

4. Hygiene and compliance

Compliance with GMP standards: The pharmaceutical industry has strict hygiene and safety requirements. TCU should comply with GMP (Good Manufacturing Practice) and relevant compliance standards for drug production. For example, TCU must be made of stainless steel to avoid leakage and rust of contaminants. The system design should be easy to clean and disinfect to prevent cross-contamination of drugs.

No pollution and no leakage: Especially in the production process of drugs, any temperature control system must ensure that no contaminants are introduced into the production environment. Therefore, the sealing, material selection, and design of pipes and interfaces of TCU need to meet high hygiene standards.

5. Controllability and automation of the system

Intelligent control system: Modern TCUs are usually equipped with advanced PID (proportional-integral-differential) controllers, which can achieve precise temperature regulation. When selecting TCU, it is recommended to choose a system with remote monitoring and alarm functions, which can provide real-time feedback on the system status to ensure that temperature fluctuations during production are within the control range.

Automation: Highly automated temperature control systems can reduce manual intervention and errors, ensure temperature stability, and also facilitate data recording, traceability, and report generation functions.

6. Energy saving and environmental protection

Energy-saving design: The energy-saving efficiency of TCU systems is particularly important in the pharmaceutical industry, because long-term operation of temperature control systems may lead to higher energy consumption. Choosing efficient heat source heat exchange systems, such as heat recovery technology (such as heat recovery heat exchangers), can reduce energy waste.

Environmental protection standards: Some TCU systems have designs that meet environmental protection standards (such as low noise and low emissions), which help reduce the impact on the environment and meet green production requirements.

7. System reliability and maintenance

Long-term stability: The pharmaceutical industry usually requires 24-hour continuous operation, so the TCU must have good durability and long-term stability. Choosing equipment with self-diagnosis function and fault alarm can ensure that problems are discovered and solved in time when they occur.

Easy to maintain and maintain: The design of the TCU system should be convenient for daily cleaning, maintenance and maintenance, reducing downtime and maintenance costs. Especially in the pharmaceutical environment that requires frequent cleaning and disinfection, the disassembly, cleaning and reassembly of the system should be simple and efficient.

8. Volume and flow matching

Capacity and flow requirements: Some production processes in the pharmaceutical industry may require large heating or cooling capacity. The flow and capacity of the TCU must match the scale of equipment such as reactors, dissolution tanks, and evaporators. Generally speaking, larger production equipment requires a large flow heat source system to maintain a constant temperature.

9. Safety

Overheat protection: The TCU should be equipped with multiple safety protection devices such as overheating, overcurrent, water shortage, and excessive pressure to prevent the equipment from operating in abnormal conditions and avoid failures or safety accidents.

1.Heater & Chiller Combo Units (SUNDI series)

(Custom Designs)

Temperature range: -120℃ ~ +350℃
High-precision, intelligent temperature control
Fully closed system to extend the service life of thermal fluid

Eleven product series

Model

SUNDI-1

SUNDI-2

SUNDI-23

SUNDI-4

SUNDI-43

SUNDI-6

SUNDI-63

SUNDI-7

SUNDI-8

SUNDI-9

SUNDI-10

Temperature range

-10 ~ +150 °C

-25 ~ +200 °C

-25 ~ +300 °C

-45 ~ +250 °C

-45 ~ +300 °C

-60 ~ +250 °C

-60 ~ +300 °C

-70 ~ +250 °C

-80 ~ +250 °C

-90 ~ +250 °C

-100 ~ +100 °C

Cooling capacity

1.5 … 15 kW

1 … 200 kW

0.45 … 200 kW

0.9 … 25 kW

0.25 … 60 kW

0.75 … 25 kW

0.4 … 15 kW

0.3 … 80 kW

0.2 … 80 kW

0.45 … 80 kW

Heating capacity

2.5 … 15 kW

2.5 … 200 kW

5.5 … 25 kW

2.5 … 60 kW

5.5 … 25 kW

2.5 … 15 kW

3 … 80 kW

3.5 … 80 kW

Pump flow pressure

20 … 75 L/min

20 … 600 L/min

35 … 150 L/min

20 … 250 L/min

35 … 150 L/min

20 … 110 L/min

20 … 400 L/min

35 … 400 L/min

Note: Any temperature range from -150℃ ~ +350℃ and any cooling capacity can be customized

2.Frequency Conversion Heater & Chiller Combo Units

(Custom Designs)

Temperature range: -80℃ ~ +250℃
High-precision, intelligent temperature control
Adopt frequency conversion control to save energy

Two product series

Model	SUNDIZ4	SUNDIZ8
Temperature range	-45 ~ +250 °C	-80 ~ +250 °C
Cooling capacity	0.9 … 60 kW	0.4 … 20 kW
Heating capacity	5.5 … 60 kW	3.5 … 15 kW
Pump flow pressure	50 … 400 L/min	35 … 250 L/min
Note: Any temperature range from -150℃ ~ +350℃ and any cooling capacity can be customized

3.Cooling and Heating Circulators

(Custom Designs)

Temperature range: -45℃ ~ +250℃
Emerson Copeland compressor, reliable quality
Self-diagnosis function, multiple safety protection devices

Two product series

Model	HR	HRT
Temperature range	-25 ~ +200 °C	-45 ~ +250 °C
Cooling capacity	1 … 15 kW	0.25 … 15 kW
Heating capacity	2.5 … 15 kW	2.5 … 15 kW
Pump flow pressure	20 … 110 L/min	20 … 110 L/min
Note: Any temperature range from -150℃ ~ +350℃ and any cooling capacity can be customized

4.Cooling and Heating Systems (WTD series)

(Custom Designs)

（Micro channel / tube reactors specialized）
Temperature range: -70℃ ~ +300℃
Wide temperature range to meet the needs of more industries

Three product series

Model	WTD-M	WTD-2T	WTD-PEX
Temperature range	-70 ~ +300 °C	-45 ~ +250 °C	-70 ~ +200 °C
Cooling capacity	1.1 … 7.5 kW	1.5 … 5.5 kW	11 … 50 kW
Heating capacity	2 … 7.5 kW	5.5 kW	38 … 50 kW
Pump flow pressure	7 … 25 L/min	25 L/min	250 L/min
Note: Any temperature range from -150℃ ~ +350℃ and any cooling capacity can be customized

5.Heating Circulators

(Custom Designs)

Temperature range: +50℃ ~ +300℃
Large heat exchange area and fast heating speed
Closed circulation system, no oil mist at high temperatures

Three product series

Model	UC-1	UC-2	UST
Temperature range	+50 ~ +170 °C	+50 ~ +300 °C	+50 ~ +300 °C
Cooling capacity	1.8 … 15 kW	1 … 130 kW	1 … 95 kW
Heating capacity	5.5 … 15 kW	3.5 … 130 kW	3.5 … 95 kW
Pump flow pressure	35 … 50 L/min	35 … 400 L/min	35 … 400 L/min
Note: Any temperature range from -150℃ ~ +350℃ and any cooling capacity can be customized

6.TCU Multi-reactors Temperature Control System

(Custom Designs)

Temperature range: -120℃ ~ +250℃
Built-in electric heating thermal oil auxiliary system
Each device is load tested for more than 12 hours

Two product series

Model	ZLF	SR
Temperature range	-25 ~ +200 °C	-45 ~ +250 °C
Pump flow pressure	150 … 750 L/min	200 … 750 L/min
Note: Any temperature range from -150℃ ~ +350℃ and any cooling capacity can be customized